Progressive supranuclear palsy: Clinical features and response to treatment in 16 patients
Identifieur interne : 002A79 ( Main/Exploration ); précédent : 002A78; suivant : 002A80Progressive supranuclear palsy: Clinical features and response to treatment in 16 patients
Auteurs : Jeffrey A. Jackson [États-Unis] ; Jankovic [États-Unis] ; Janet Ford [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 1983-03.
Abstract
Among 415 patients with parkinsonism, 16 (3.9%) had findings of progressive supranuclear palsy (PSP). This report reviews the clinical features and response to drug therapy in those 16 patients. Anticholinergic drugs failed to benefit any of the 5 patients treated, while presynaptic dopaminergic drugs (Sinemet or amantadine) were beneficial in only 5 of 22 patient trials. Alternatively, dopamine agonists (bromocriptine and pergolide) caused improvement in 9 of 14 patient trials despite the fact that all but 1 of these patients had previously failed to respond to presynaptic dopaminergic drugs. Dopamine agonists such as bromocriptine and pergolide may be useful in some patients with PSP.
Url:
DOI: 10.1002/ana.410130308
Affiliations:
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<front><div type="abstract" xml:lang="en">Among 415 patients with parkinsonism, 16 (3.9%) had findings of progressive supranuclear palsy (PSP). This report reviews the clinical features and response to drug therapy in those 16 patients. Anticholinergic drugs failed to benefit any of the 5 patients treated, while presynaptic dopaminergic drugs (Sinemet or amantadine) were beneficial in only 5 of 22 patient trials. Alternatively, dopamine agonists (bromocriptine and pergolide) caused improvement in 9 of 14 patient trials despite the fact that all but 1 of these patients had previously failed to respond to presynaptic dopaminergic drugs. Dopamine agonists such as bromocriptine and pergolide may be useful in some patients with PSP.</div>
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